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These studies demonstrated that fasting upregulates the plasma membrane OCTN2 carnitine transporter in the liver, heart, kidneys and in rats with strong caloric restriction, additionally in skeletal muscle [111]

Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

And metabolic changes that make regaining lost weight easier and losing it again harder

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